In many cases, treatment can reduce the risk of complications from polycythemia vera and ease signs and symptoms.Treatment might include: 1. After many years of PV, some people can develop another type of blood cancer known as leukemia. But proper medical care can help ease signs, symptoms and complications of this disease. Talk to your doctor about which medications and treatment options are best for you. feeling lightheaded or dizzy. Our website services, content, and products are for informational purposes only. All rights reserved. Headache 3. The red blood cells are mostly affected. https://www.uptodate.com/contents/search. Mayo Clinic. If it forms in the blood vessels of your heart, it can lead to a heart attack. Normally, your body regulates the number of each of the three types of blood cells you have — red blood cells, white blood cells and platelets. Symptoms of the following disorders can be similar to those of polycythemia vera. Otherwise, the rest of the cells are in a continuous state of death and division. If it forms in the blood vessels of your brain, it can lead to a stroke. Polycythemia vera often does not cause early signs or symptoms. Tinnitus is a buzzing sound in your ears that doesn’t stop and can vary from being unnoticeable to causing severe discomfort. The most common place for a DVT to develop is in the legs, but it can occur in veins of the arms, abdomen, and pelvis too. Excessive sweating 9. The symptoms of MPNs vary based on the type of disease and the patient’s unique circumstances. It usually develops slowly, and you might have it for years without knowing. Why Does Polycythemia Vera Cause Leg Pain? When symptoms first start, they can be mild enough to miss. Tefferi A. Prognosis and treatment of polycythemia vera. Blurred vision 8. Arteries are blood vessels that carry oxygen-rich blood away from your heart to other parts of your body. Others might have: 1. Other conditions may cause the same signs and symptoms. Current Treatment Options in Oncology. breathlessness. Your doctor may recommend a bone marrow transplant for severe cases of PV. These excess cells thicken your blood, slowing its flow, which may cause serious problems, such as blood clots. Make a donation. coughing up blood. Weakness 6. As the blood flow reduces due to the thickened viscosity, as a result many parts of the body become oxygen starved. I concluded that increasing levels of fatigue were also due to getting older and not retiring when I was 65 years old. All 3 can be associated with splenomegaly, cytopenias, profound constitutional symptoms, and an increased risk of transformation to MF or acute leukemia. It causes your bone marrow to make too many red blood cells. The high levels of blood cells make your blood thicker than normal, so blood clots can form more easily. pain, swelling, redness and tenderness in one of your legs. Over time, this will help your health care team know how to best manage this long-term diagnosis so that you can experience the best quality of life. Taking blood out of your veins. The cause of the gene mutation in polycythemia vera is unknown, but it's generally not inherited from your parents. … Polycythemia vera (adult). Dizziness 4. One of the most obvious symptoms of polycythemia vera, which causes blood flow to slow down considerably, is angina, or chest pain and discomfort. Joint pains also are common in patients with polycythemia vera. AskMayoExpert. Polycythemia Vera – What Is PV, Symptoms, Diagnosis & Treatment. 26th ed. Polycythemia vera – A chronic blood cancer. Early symptoms are related to blood hyperviscosity due to polycythemia. Numbness, tingling, burning or weakness in your hands, feet, arms or legs 12. Polycythemia vera-associated complications: Pathogenesis, clinical manifestations, and effects on outcomes. Unusual bleedi… Griesshammer M, et al. This causes serious health problems. Secondary polycythemia is a general term for the overproduction of red blood cells that occurs as a result of (secondary to) a known cause. Tender redness of the palms and soles is called erythromelalgia. 2019. This can lead to strokes or tissue and organ damage. National Heart, Lung, and Blood Institute. What is polycythemia vera? Polycythemia vera. Polycythemia Vera: Prognosis and Life Expectancy, Complications and Risks of Polycythemia Vera, pulmonary embolisms, caused by blood clots in the blood vessels of the lung. More-specific symptoms of polycythemia vera include: Make an appointment with your doctor if you have signs or symptoms of polycythemia vera. But in general, there are a handful of symptoms to look for, since they may mark the progression of the disease: Common Primary Myelofibrosis (MF) Symptoms Tiredness, weakness, or shortness of … Annals of Hematology. This limits the amount of oxygen that can get to organs and tissue. Some people might develop vague symptoms such as headache, dizziness, fatigue and blurred vision. These conditions require treatments that focus on both PV and the specific type of leukemia. By preventing oxygen-rich blood from reaching the heart, polycythemia vera can even lead to heart failure . Comparisons may be useful for a differential diagnosis. Some possible signs and symptoms of PV include: These symptoms can also be mistaken for other conditions. Polycythemia Vera is caused by the over the manufacture of red blood cells. A pulmonary embolism occurs when a blood clot happens in your lungs, often from a DVT moving to the lungs from somewhere else in the body. More-specific symptoms of polycythemia vera include: 1. A variety of treatment options are also available for other symptoms and conditions associated with PV. Polycythemia Vera: Doctor Discussion Guide. Polycythaemia also increases your risk of heart attack and stroke. 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